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ID 113516
Author
Min, Hongzhong The University of Tokushima
Kudo, Eiji The University of Tokushima
Hino, Akiko The University of Tokushima
Iwahana, Hiroyuki The University of Tokushima
Keywords
p53 gene
Bladder cancer
Rat
N-butyl-N-(4-hydroxybutyl)nitrosamine
PCR-SSCP
Content Type
Journal Article
Description
We analyzed p53 mutations in 17 N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder transitional cell carcinomas (TCCs) with or without areas of squamous cell carcinoma (SCC) of Long–Evans Cinnamon (LEC) and F344 rats, and in 7 N-methyl-N-nitrosourea-induced colon adenocarcinomas of LEC rats by polymerase chain reaction-single strand conformation polymorphism analysis and DNA sequencing. Of these bladder tumors, one TCC with moderately differentiated SCC had a T to G transversion mutation at codon 141, leading to a Val to Gly amino acid change. No p53 mutation was found in colon adenocarcinomas. Thus a p53 gene mutation seems infrequent in these rat bladder and colon carcinogenesis models even in the late stage.
Journal Title
Cancer Letters
ISSN
03043835
NCID
AA00598513
AA1152274X
Publisher
Elsevier
Volume
117
Issue
1
Start Page
81
End Page
86
Published Date
1997-07-15
Remark
本論文は,著者Hongzhong Minの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences
Institute of Advanced Medical Sciences
Medical Sciences