ID 113516
著者
Min, Hongzhong The University of Tokushima
工藤, 英治 The University of Tokushima
Hino, Akiko The University of Tokushima
Iwahana, Hiroyuki The University of Tokushima
キーワード
p53 gene
Bladder cancer
Rat
N-butyl-N-(4-hydroxybutyl)nitrosamine
PCR-SSCP
資料タイプ
学術雑誌論文
抄録
We analyzed p53 mutations in 17 N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder transitional cell carcinomas (TCCs) with or without areas of squamous cell carcinoma (SCC) of Long–Evans Cinnamon (LEC) and F344 rats, and in 7 N-methyl-N-nitrosourea-induced colon adenocarcinomas of LEC rats by polymerase chain reaction-single strand conformation polymorphism analysis and DNA sequencing. Of these bladder tumors, one TCC with moderately differentiated SCC had a T to G transversion mutation at codon 141, leading to a Val to Gly amino acid change. No p53 mutation was found in colon adenocarcinomas. Thus a p53 gene mutation seems infrequent in these rat bladder and colon carcinogenesis models even in the late stage.
掲載誌名
Cancer Letters
ISSN
03043835
cat書誌ID
AA00598513
AA1152274X
出版者
Elsevier
117
1
開始ページ
81
終了ページ
86
発行日
1997-07-15
備考
本論文は,著者Hongzhong Minの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
先端酵素学研究所
医学系