| ID | 110435 |
| Title Transcription | メサンギウム サイボウ ゾウショク ニカンスル アラタナ セイギョ インシ ト ビョウヘン ヨクシ ニカンスル ケンキュウ
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| Title Alternative | A novel mechanism of growth regulation on mesangial proliferation
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| Author |
Doi, Toshio
Department of Laboratory Medicine, The University of Tokushima School of Medicine
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| Keywords | Gas 6
22-oxa-calcitriol
mesangial proliferation
Warfarin
vitamin K
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| Content Type |
Journal Article
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| Description | Mesangial proliferation is a common feature of many glomerular diseases, therefore, understanding the regulatory mechanism is important for the treatment of glomerular diseases. The present study showed growth arrest gene-6 (Gas6) is a new autocrine growth factor of mesangial cells and warfarin inhibited mesangial proliferation by inhibiting γ-carboxylation of Gas 6 in vitro and in vivo. We also found vitamin D anlog (22-oxa-calcitriol) is a new growth regulator for mesangial cells in vivo. These results indicate that these compounds have considerable potential for use as therapeutic strategy in the treatment of progressive glomerular disease.
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| Journal Title |
四国医学雑誌
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| ISSN | 00373699
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| NCID | AN00102041
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| Publisher | 徳島医学会
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| Volume | 56
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| Issue | 1
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| Start Page | 25
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| End Page | 28
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| Sort Key | 25
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| Published Date | 2000-02-25
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| FullText File | |
| language |
jpn
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| TextVersion |
Publisher
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| departments |
Medical Sciences
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