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ID 114405
Author
Matsuura, Motokazu Tokushima Red Cross Hospital KAKEN Search Researchers
Hann, Mike US Navy Hospital
Keywords
sarcoidosis
granulomatous interstitial nephritis
immunohistochemistry
hypercalcemia
nephrosclerosis
Content Type
Journal Article
Description
A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed nonspecific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Corticosteroid improved the kidney function, and reduced the serum levels of calcium and angiotensin-converting enzyme. Sarcoid nephropathy may be caused by the combination of several sarcoidosis-associated pathophysiological conditions and a comprehensive kidney examination should be performed to assess the type of injury when determining a treatment strategy.
Journal Title
Internal Medicine
ISSN
13497235
Publisher
The Japanese Society of Internal Medicine
Volume
58
Issue
5
Start Page
679
End Page
684
Published Date
2019-03-01
Rights
The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences
University Hospital