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ID 114405
著者
松浦, 元一 Tokushima Red Cross Hospital KAKEN研究者をさがす
Hann, Mike US Navy Hospital
キーワード
sarcoidosis
granulomatous interstitial nephritis
immunohistochemistry
hypercalcemia
nephrosclerosis
資料タイプ
学術雑誌論文
抄録
A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed nonspecific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Corticosteroid improved the kidney function, and reduced the serum levels of calcium and angiotensin-converting enzyme. Sarcoid nephropathy may be caused by the combination of several sarcoidosis-associated pathophysiological conditions and a comprehensive kidney examination should be performed to assess the type of injury when determining a treatment strategy.
掲載誌名
Internal Medicine
ISSN
13497235
出版者
The Japanese Society of Internal Medicine
58
5
開始ページ
679
終了ページ
684
発行日
2019-03-01
権利情報
The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院