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ID 111624
Title Alternative
高リン食は白色脂肪組織の脂肪合成を抑制する
Author
Imi, Yukiko Tokushima University
Yabiki, Norie Tokushima University
Abuduli, Maerjianghan Tokushima University
Keywords
dietary phosphate
white adipose tissue
insulin
lipogenesis
lipolysis
Content Type
Thesis or Dissertation
Description
Excessive phosphate intake has been positively associated with renal and vascular dysfunction, conversely negatively associated with body fat accumulation. We investigated the effect of a high-phosphate diet on the expression of lipid metabolic genes in white adipose tissue and liver. Male 8-week-old Sprague–Dawley rats were fed a control diet containing 0.6% phosphate or a high-phosphate diet containing 1.5% phosphate for 4 weeks. In comparison to the control group, the HP group showed a significantly lower body fat mass and fasting plasma insulin level alongside decreased lipogenic and increased lipolytic gene expression in visceral fat. Additionally, the expression of genes involved in hepatic lipogenesis, hepatic glycogenesis, and triglyceride accumulation decreased in the high-phosphate group. Exogenous phosphate, parathyroid hormone, and fibroblast growth factor 23 did not directly affect the expression of lipolytic or lipogenic genes in 3T3-L1 adipocytes and HepG2 hepatocytes. Thus, the high-phosphate diet suppressed the activity of white adipose tissue by increasing lipolytic gene expression and decreasing lipogenic gene expression. These effects could have been caused by the lowered fasting plasma insulin level that occurred in response to the high-phosphate diet, but were not directly caused by the increases in plasma phosphate or phosphaturic hormones.
Journal Title
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
NCID
AA10710201
AA12091064
Publisher
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
Volume
63
Issue
3
Start Page
181
End Page
191
Published Date
2018-11-01
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yukiko Imiの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
© 2018 Society for Free Radical Research Japan
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3150号
Diploma Number
甲栄第259号
Granted Date
2018-03-23
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences