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ID 111624
タイトル別表記
高リン食は白色脂肪組織の脂肪合成を抑制する
著者
伊美, 友紀子 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Yabiki, Norie Tokushima University
Abuduli, Maerjianghan Tokushima University
キーワード
dietary phosphate
white adipose tissue
insulin
lipogenesis
lipolysis
資料タイプ
学位論文
抄録
Excessive phosphate intake has been positively associated with renal and vascular dysfunction, conversely negatively associated with body fat accumulation. We investigated the effect of a high-phosphate diet on the expression of lipid metabolic genes in white adipose tissue and liver. Male 8-week-old Sprague–Dawley rats were fed a control diet containing 0.6% phosphate or a high-phosphate diet containing 1.5% phosphate for 4 weeks. In comparison to the control group, the HP group showed a significantly lower body fat mass and fasting plasma insulin level alongside decreased lipogenic and increased lipolytic gene expression in visceral fat. Additionally, the expression of genes involved in hepatic lipogenesis, hepatic glycogenesis, and triglyceride accumulation decreased in the high-phosphate group. Exogenous phosphate, parathyroid hormone, and fibroblast growth factor 23 did not directly affect the expression of lipolytic or lipogenic genes in 3T3-L1 adipocytes and HepG2 hepatocytes. Thus, the high-phosphate diet suppressed the activity of white adipose tissue by increasing lipolytic gene expression and decreasing lipogenic gene expression. These effects could have been caused by the lowered fasting plasma insulin level that occurred in response to the high-phosphate diet, but were not directly caused by the increases in plasma phosphate or phosphaturic hormones.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
cat書誌ID
AA10710201
AA12091064
出版者
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
63
3
開始ページ
181
終了ページ
191
発行日
2018-11-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yukiko Imiの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2018 Society for Free Radical Research Japan
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3150号
学位記番号
甲栄第259号
学位授与年月日
2018-03-23
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系