ID 109522
Title Alternative
テストステロン測定系の改良により日本女性における多嚢胞性卵巣症候群患者の診断効率は改善した
Diagnosis of PCOS by Revised T Assay
Author
Niki, Hirobumi the University of Tokushima
Kinouchi, Riyo the University of Tokushima
Kawami, Takako the University of Tokushima
Keywords
PCOS
testosterone
diagnosis
LH
assay
Content Type
Thesis or Dissertation
Description
Hyperandrogenemia has become an important factor in the diagnosis of polycystic ovary syndrome (PCOS), in Japan as well as Western countries, since the Japanese PCOS diagnostic criteria were revised in 2007. The revised electrochemiluminescence immunoassay (ECLIA) reagent for total testosterone (T) (ECLusys TESTO II ; New T assay), which has lower cross-reactivity with DHEA-S than the previous reagent (ECLusys TESTO I ; Old T assay), has recently been developed. We studied the improvement between New and Old T assays in regards to the diagnostic performance of serum T for patients with PCOS. Serum T levels were measured in both normal women (Control, n=92) and PCOS patients (n=86). The rate of elevated T using each kit was significantly higher in the PCOS group than in the Control group, and significantly higher using New T assay (38/86, 44.2%) compared with Old T assay (26/86, 30.2%). A significant correlation was found between T level and body mass index, but not LH level. Furthermore, higher detection rates of hormonal abnormalities were seen in PCOS patients using combined measurement of both T and LH (63/80) compared with single measurement of either T (37/80) or LH (36/80). Therefore, the serum T assay is essential for the diagnosis of PCOS, and New T assay combined with the LH assay may improve the diagnostic process for PCOS.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
61
Issue
1-2
Start Page
65
End Page
71
Sort Key
65
Published Date
2014-02
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405131003.pdf
論文本文 : LID201503191001.pdf
本論文は,著者Hirobumi Nikiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2739号
Diploma Number
甲医第1200号
Granted Date
2014-03-19
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital