ID 109522
タイトル別表記
テストステロン測定系の改良により日本女性における多嚢胞性卵巣症候群患者の診断効率は改善した
Diagnosis of PCOS by Revised T Assay
著者
仁木, 博文 徳島大学大学院医学研究科(医学専攻)
キノウチ, リヨ the University of Tokushima
カワミ, タカコ the University of Tokushima
キーワード
PCOS
testosterone
diagnosis
LH
assay
資料タイプ
学位論文
抄録
Hyperandrogenemia has become an important factor in the diagnosis of polycystic ovary syndrome (PCOS), in Japan as well as Western countries, since the Japanese PCOS diagnostic criteria were revised in 2007. The revised electrochemiluminescence immunoassay (ECLIA) reagent for total testosterone (T) (ECLusys TESTO II ; New T assay), which has lower cross-reactivity with DHEA-S than the previous reagent (ECLusys TESTO I ; Old T assay), has recently been developed. We studied the improvement between New and Old T assays in regards to the diagnostic performance of serum T for patients with PCOS. Serum T levels were measured in both normal women (Control, n=92) and PCOS patients (n=86). The rate of elevated T using each kit was significantly higher in the PCOS group than in the Control group, and significantly higher using New T assay (38/86, 44.2%) compared with Old T assay (26/86, 30.2%). A significant correlation was found between T level and body mass index, but not LH level. Furthermore, higher detection rates of hormonal abnormalities were seen in PCOS patients using combined measurement of both T and LH (63/80) compared with single measurement of either T (37/80) or LH (36/80). Therefore, the serum T assay is essential for the diagnosis of PCOS, and New T assay combined with the LH assay may improve the diagnostic process for PCOS.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
1-2
開始ページ
65
終了ページ
71
並び順
65
発行日
2014-02
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405131003.pdf
論文本文 : LID201503191001.pdf
本論文は,著者Hirobumi Nikiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2739号
学位記番号
甲医第1200号
学位授与年月日
2014-03-19
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院