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ID 117559
Author
Nakanishi, Nobuto Tokushima University
Hara, Kanako Tokushima University
Matsuo, Masafumi Kobe Gakuin University
Keywords
titin
muscle
diaphragm
atrophy
physical dysfunction
biomarker
urine
post-intensive care syndrome
nutrition
rehabilitation
Content Type
Journal Article
Description
Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.
Journal Title
Journal of Clinical Medicine
ISSN
20770383
Publisher
MDPI
Volume
10
Issue
4
Start Page
614
Published Date
2021-02-06
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences