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ID 115648
Author
Yamazaki, Kiyohiro Ehime University
Yoshino, Yuta Ehime University
Kawabe, Kentaro Ehime University
Ibuki, Tomomasa Ehime University
Ochi, Shinichiro Ehime University
Mori, Yoko Ehime University
Ozaki, Yuki Ehime University
Ueno, Shu-ichi Ehime University
Keywords
schizophrenia
ATP-binding cassette sub-family A member 7 gene
single nucleotide polymorphism
rs3764650
mRNA expression
Content Type
Journal Article
Description
Introduction: Although ATP-binding cassette sub-family A member 7 gene (ABCA7) is known to be associated with Alzheimer’s disease, the relationship between ABCA7 and schizophrenia has been unknown.
Methods: Schizophrenia patients (n = 50; 24 males, 62.1 ± 0.50 years old) and age- and sex-matched healthy controls (n = 50) were recruited for the mRNA analysis. Additionally, a case-control study for the rs3764650 genotypes was performed with 1308 samples (control subjects; n = 527, schizophrenia patients; n = 781). All participants were Japanese, unrelated to each other, and living in the same area.
Results: The distributions of the rs3764650 genotypes in schizophrenia patients were not different from that of controls. However, the ABCA7 mRNA expression levels in schizophrenia patients were significantly higher than those in controls by a logistic regression analysis. Additionally, the ABCA7 mRNA expression levels in schizophrenia patients were correlated with the rs3764650 genotypes in a dose-dependent manner.
Discussion: The ABCA7 mRNA expression levels in peripheral blood with the rs3764650 genotypes may be related to pathological mechanisms in schizophrenia and may be a biological marker for schizophrenia.
Journal Title
Neuropsychiatric Disease and Treatment
ISSN
11782021
Publisher
Dove Medical Press
Volume
16
Start Page
441
End Page
446
Published Date
2020-02-13
Rights
© 2020 Yamazaki et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
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language
eng
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departments
Medical Sciences