Yamazaki, Kiyohiro Ehime University
Yoshino, Yuta Ehime University
Kawabe, Kentaro Ehime University
Ibuki, Tomomasa Ehime University
Ochi, Shinichiro Ehime University
Mori, Yoko Ehime University
Ozaki, Yuki Ehime University
上野, 修一 Ehime University
ATP-binding cassette sub-family A member 7 gene
single nucleotide polymorphism
Introduction: Although ATP-binding cassette sub-family A member 7 gene (ABCA7) is known to be associated with Alzheimer’s disease, the relationship between ABCA7 and schizophrenia has been unknown.
Methods: Schizophrenia patients (n = 50; 24 males, 62.1 ± 0.50 years old) and age- and sex-matched healthy controls (n = 50) were recruited for the mRNA analysis. Additionally, a case-control study for the rs3764650 genotypes was performed with 1308 samples (control subjects; n = 527, schizophrenia patients; n = 781). All participants were Japanese, unrelated to each other, and living in the same area.
Results: The distributions of the rs3764650 genotypes in schizophrenia patients were not different from that of controls. However, the ABCA7 mRNA expression levels in schizophrenia patients were significantly higher than those in controls by a logistic regression analysis. Additionally, the ABCA7 mRNA expression levels in schizophrenia patients were correlated with the rs3764650 genotypes in a dose-dependent manner.
Discussion: The ABCA7 mRNA expression levels in peripheral blood with the rs3764650 genotypes may be related to pathological mechanisms in schizophrenia and may be a biological marker for schizophrenia.
Neuropsychiatric Disease and Treatment
Dove Medical Press
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