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ID 114793
Author
Ebe, K Takao Hospital|Japan Low Carbohydrate Diet Promotion Association
Bando, Hiroshi Japan Low Carbohydrate Diet Promotion Association|Tokushima University KAKEN Search Researchers
Muneta, T Japan Low Carbohydrate Diet Promotion Association|Muneta Maternity Clinic
Bando, M Tokushima University
Yonei, Y Doshisha University
Keywords
Low Carbohydrate Diet
Continuous Glucose Monitoring
FreeStyle Libre Pro
Flash Glucose Monitoring
Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
Japan LCD Promotion Association (JLCDPA)
Content Type
Journal Article
Description
Diabetes has been a crucial medical and social problem worldwide. For adequate nutritional therapy, there have been discussions concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD). We have investigated glucose variability of diabetic patients applying CR, LCD, continuous glucose monitoring (CGM) and applied FreeStyle Libre which is flash glucose monitoring (FGM). The patient is a 40-year-old female with type 2 diabetes mellitus (T2DM), who showed BMI 20.7, postprandial blood glucose 257 mg/dL. HbA1c 12.1%, Glycoalbumin 31.6% (11.6-16.4), serum C-peptide 2.0 ng/ml and unremarkable data of liver function, renal, lipids. She was provided the intervention of three stages, which are i) CR with 60% carbohydrate in Day 1-2, ii) LCD meal with 12% carbohydrate in Day 3-5; iii) LCD + Sodium-glucose cotransporter 2 (SGLT2) inhibitor (Ipragliflozin L-Proline 50mg) in Day 6-12. The glucose profile was measured by FreeStyle Libre Pro (Abbott) for 14 days. The daily profile of blood glucose was abruptly decreased on Day 6. Time percentage of satisfactory blood glucose 70-180 mg/dL (/24h) was 0%, 0%, 2%, 14%, 0%, 54%, 100% in Day 1-7, respectively. These results suppose the acute clinical efficacy of SGLT2 inhibitor, and this report would become a reference for future diabetic practice and research.
Journal Title
Diabetes Research : Open Access
Publisher
Asploro
Volume
2
Issue
S1
Start Page
1
End Page
8
Published Date
2020-01-06
Rights
© 2020 Ebe K, Bando H, Muneta T, Bando M, Yonei Y. This is an open-access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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language
eng
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departments
Medical Sciences