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ID 117178
Author
Hayashi, Kenji Hayashi Hospital
Bando, Hiroshi Hayashi Hospital|Tokushima University|Japan Low Carbohydrate Diet Promotion Association KAKEN Search Researchers
Miki, Kazuya Hayashi Hospital
Yasuoka, Eri Hayashi Hospital
Kamoto, Asami Hayashi Hospital
Yasuoka, Tatsuo Hayashi Hospital
Keywords
Glucagon-like peptide 1 receptor agonist (GLP-1 RA)
semaglutide
Rybelsus
sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC)
bioavailability
Content Type
Journal Article
Description
Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have been attracted attention for various beneficial effects. Among them, oral semaglutide (Rybelsus) was developed using the absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). The relationship between the bioavailability and post-dose fasting time period was analyzed. The results showed that i) its bioavailability with drinking 50mL and 120mL of water together was almost similar, ii) bioavailability for 240mL intake was about 2/3 of 50-120mL, iii) general availability would be about 1.4% for 50-120ml water, and 0.8% for 240mL of water. Tolerability and safety of Rybelsus showed similar results for healthy subjects, patients with renal and/or hepatic impairment. From mentioned above, Rybelsus has been one of the topic agents with characteristic mechanism of SNAC and clinical benefit of GLP-1RA. It will be expected to be applied widely in actual diabetic practice.
Journal Title
International Journal of Complementary & Alternative Medicine
ISSN
23811803
Publisher
MedCrave Publishing
Volume
15
Issue
3
Start Page
151
End Page
152
Published Date
2022-06-03
Rights
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and build upon your work non-commercially.
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences