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ID 112034
Title Alternative
肝細胞癌患者における術前血清CEA値上昇は上皮間葉転換を介して予後不良と関連する
Elevated Preoperative Serum CEA Level Is with Hepatocellular Carcinoma with Poor Prognosis Through the Epithelial-Mesenchymal Transition
Author
Yoshikawa, Masato The University of Tokushima
Higashijima, Jun The University of Tokushima KAKEN Search Researchers
Ishikawa, Daichi The University of Tokushima
Teraoku, Hiroki The University of Tokushima
Takata, Atsushi The University of Tokushima
Yoshimoto, Toshiaki The University of Tokushima
Keywords
CEA
CEACAM
epithelial mesenchymal transition
hepatocellular carcinoma
Content Type
Thesis or Dissertation
Description
Background: Serum carcinoembryonic antigen (CEA) is used as an indicator of tumor progression in a variety of carcinomas. A subset of patients with hepatocellular carcinoma (HCC) exhibit increased serum CEA level, but the significance of this is unclear. In this study, we investigated the prognosis of patients with HCC with increased serum CEA, and explored the correlations with expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and epithelial–mesenchymal transition (EMT) and tumor angiogenesis. Materials and Methods: One hundred and twenty-three patients with HCC who underwent radical resection were divided into two groups according to a cut-off value of 5.0 ng/ml for serum CEA: high (n=24) and normal (n=99) groups. We compared the clinicopathological factors with serum CEA levels and its correlations with CEACAM1 expression, EMT-related factors and microvessel density (MVD) of tumor tissues by immunohistochemistry. Results: In the high CEA group, the disease-free survival (DFS) rate was significantly worse than in the normal CEA group. Multivariate analysis revealed that a high CEA level was an independent factor predictive of recurrence. Furthermore, increased serum CEA levels were positively correlated with CEACAM1 expression. Moreover, CEACAM1 expression was positively correlated with expression of EMT-related factors and MVD of tumor tissues. Conclusion: Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in HCC through EMT and tumor angiogenesis.
Journal Title
Anticancer Research
ISSN
02507005
17917530
NCID
AA10625860
AA12440673
Publisher
International Institute of Anticancer Research
Volume
37
Issue
3
Start Page
1169
End Page
1175
Published Date
2017-03-01
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者MASATO YOSHIKAWAの学位論文として提出され, 学位審査・授与の対象となっている。
公開に関する許諾確認は著者・編集事務局間のメールによる。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3204号
Diploma Number
甲医第1379号
Granted Date
2018-07-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital