Kakutani, Hideki Kanaiso Hospital
Kato, Yoshikane Kanaiso Hospital
Fujikawa, Tomomi Kanaiso Hospital
Kawata, Takafumi Kanaiso Hospital
Yamamoto, Masami Kanaiso Hospital
Wada, Koichi Kanaiso Hospital
Ishikura, Kazuyo Kanaiso Hospital
Shirai, Yujiro Kanaiso Hospital
Narutaki, Miyuki Kanaiso Hospital
Kanazawa, Setsuko Kanaiso Hospital
Matsuzaki, Sayuri Kanaiso Hospital
Waka, Shinnichi Kanaiso Hospital
Chronic kidney disease
Erythropoiesis stimulating agent
Cardio renal anemia syndrome
Background: Authors and colleagues have continued clinical research for hemodialysis patients. Currently, a pilot study presents intervention of carnitine for changes of the body composition.
Subjects and Methods: Subjects were six patients on hemodialysis with intervention of carnitine (group 1). Average data were 74.3 years, 65.4 kg, 22.6 in BMI. As levocarnitine, L-Cartin FF injection 1000 mg was administered three times a week for six months. Group 2 has six control patients for age-, sex-, body weight, BMI-matched (group 2). Body composition of muscle and fat tissues were measured by InBody 770 on 0 and 6 months.
Results: In group 1, muscle volume and skeletal muscle showed increasing tendency without statistical significance. In contrast, there were significant decreases of body fat volume (22.3 kg vs 20.5 kg, 39.0% vs 35.8%) (p<0.05). No significant differences were found in hemoglobin, total protein, albumin and Cardio-Thoracic Ratio (CTR) of chest X-ray. Group 2 showed no significant changes.
Discussion and Conclusion: Hemodialysis patients often have muscular reduction. Previous reports showed improved lean body mass by carnitine administration, which may support our result. These results from current pilot study would be expected to become useful reference data in the pathophysiological investigation in patients on hemodialysis.
Edelweiss Journal of Biomedical Research and Review
© 2020 Kakutani H, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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