体性感覚誘発電位(SEP)および脳波へのinsulin低血糖の影響

The effects of insulin-induced hypoglycemia on the central nervous system were studied by somatosensory evoked potential (SEP), with 8 schizophrenic patients (31~47 y. o.), during the 'kleine Insulinbehandlung'. In each of three experimental session on different days, human regular insulin was injected subcutaneously to the patients, whose consciousness level was lowered to the stage of somnolence, and recovered by intake of a glucose solution (100 g). EEG containig SEPs evoked by electric simuli was derived from the two derivations (1 st ch: C3'→A1+2, 4 th ch: C3'→F3'). In the experimental session, EEG containing SEPs was recorded before and 20, 40, 60, 80, 100 and 120 min after the injection of insulin, and 20 min after intake of glucose. Consecutive changes of group mean SEP were studied. Individual SEPs were subjected to the component analysis, and to the statistical assessment together with EEG power%.
As a result, the middle and long latency components of SEP significantly prolonged in latency and significantly decreased in amplitude 60 min after the injection of insulin. On the other hand, the short latency components of SEP significantly prolonged in latency 100~120 min after the injection of insulin. These results suggested that the activity of cerebral cortex was inhibited, but subcortex was not affected to hypoglycemia in the early stage. In the results of the present study with SEP, the noradrenergic activities in the early stage of hypoglycemia, observed with AEP previously reported, were not confirmed.

著者英表記誤記あり(誤)Keuji Uemura →(正)Keiji Uemura