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ID 112075
タイトル別表記
The effects of insulin-induced hypoglycemia on the human SEP (Somatosensory Evoked Potential) and EEG
著者
伊藤, 嘉信 徳島大学
河村, 一郎 徳島大学
大蔵, 雅夫 徳島大学
生田, 琢己 徳島大学
苅舎, 健治 徳島大学
香川, 公一 徳島大学
植村, 桂次 徳島大学
キーワード
somatosensory evoked potential
EEG
hypoglycemia
insulin
資料タイプ
学術雑誌論文
抄録
The effects of insulin-induced hypoglycemia on the central nervous system were studied by somatosensory evoked potential (SEP), with 8 schizophrenic patients (31~47 y. o.), during the 'kleine Insulinbehandlung'. In each of three experimental session on different days, human regular insulin was injected subcutaneously to the patients, whose consciousness level was lowered to the stage of somnolence, and recovered by intake of a glucose solution (100 g). EEG containig SEPs evoked by electric simuli was derived from the two derivations (1 st ch: C3'→A1+2, 4 th ch: C3'→F3'). In the experimental session, EEG containing SEPs was recorded before and 20, 40, 60, 80, 100 and 120 min after the injection of insulin, and 20 min after intake of glucose. Consecutive changes of group mean SEP were studied. Individual SEPs were subjected to the component analysis, and to the statistical assessment together with EEG power%.
As a result, the middle and long latency components of SEP significantly prolonged in latency and significantly decreased in amplitude 60 min after the injection of insulin. On the other hand, the short latency components of SEP significantly prolonged in latency 100~120 min after the injection of insulin. These results suggested that the activity of cerebral cortex was inhibited, but subcortex was not affected to hypoglycemia in the early stage. In the results of the present study with SEP, the noradrenergic activities in the early stage of hypoglycemia, observed with AEP previously reported, were not confirmed.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
54
2
開始ページ
185
終了ページ
194
並び順
185
発行日
1998-04-25
備考
著者英表記誤記あり(誤)Keuji Uemura →(正)Keiji Uemura
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系