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ID 115662
Author
Nanri, Hinako Showa University
Nishida, Yuichiro Saga University
Nakamura, Kazuyo St. Mary’s College
Tanaka, Keitaro Saga University
Naito, Mariko Nagoya University
Yin, Guang Seinan Jo Gakuin University
Hamajima, Nobuyuki Nagoya University
Takashima, Naoyuki Shiga University of Medical Science
Suzuki, Sadao Nagoya City University
Nindita, Yora Kagoshima University
Kohno, Michiko Kyushu University
Uemura, Hirokazu The University of Tokushima KAKEN Search Researchers
Koyama, Teruhide Kyoto Prefectural University of Medicine
Hosono, Satoyo Aichi Cancer Center Research Institute
Mikami, Haruo Chiba Cancer Center
Kubo, Michiaki RIKEN
Tanaka, Hideo Aichi Cancer Center Research Institute
Keywords
dietary pattern
factor analysis
β-adrenergic receptor (ADRβ)
polymorphism
triglyceride
Content Type
Journal Article
Description
Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35–69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADRβ3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADRβ polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADRβ3 polymorphism modifies the effects of the bread pattern on triglyceride levels.
Journal Title
Nutrients
ISSN
20726643
Publisher
MDPI
Volume
8
Issue
9
Start Page
545
Published Date
2016-09-06
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version)
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language
eng
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departments
Medical Sciences