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ID 115662
著者
Nanri, Hinako Showa University
Nishida, Yuichiro Saga University
Nakamura, Kazuyo St. Mary’s College
Tanaka, Keitaro Saga University
Naito, Mariko Nagoya University
Yin, Guang Seinan Jo Gakuin University
Hamajima, Nobuyuki Nagoya University
Takashima, Naoyuki Shiga University of Medical Science
Suzuki, Sadao Nagoya City University
Nindita, Yora Kagoshima University
Kohno, Michiko Kyushu University
上村, 浩一 The University of Tokushima KAKEN研究者をさがす
Koyama, Teruhide Kyoto Prefectural University of Medicine
Hosono, Satoyo Aichi Cancer Center Research Institute
Mikami, Haruo Chiba Cancer Center
Kubo, Michiaki RIKEN
Tanaka, Hideo Aichi Cancer Center Research Institute
キーワード
dietary pattern
factor analysis
β-adrenergic receptor (ADRβ)
polymorphism
triglyceride
資料タイプ
学術雑誌論文
抄録
Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35–69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADRβ3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADRβ polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADRβ3 polymorphism modifies the effects of the bread pattern on triglyceride levels.
掲載誌名
Nutrients
ISSN
20726643
出版者
MDPI
8
9
開始ページ
545
発行日
2016-09-06
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系