Abe, Shogo Tokushima University
Ueno, Misako Tokushima University
Nishitani, Mami Tokushima University
Akamatsu, Tetsuya Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sato, Takumi Tokushima University
Shimoda, Marie Matsuyama Co., Ltd.
Kanaoka, Hiroki Matsuyama Co., Ltd.
Nii, Yoshitaka Tokushima Prefectural Industrial Technology Center
Yamasaki, Hiroko Matsuyama Co., Ltd.
citrus peel extract
cell proliferation and differentiation
Citrus sudachi is a well-known fruit in Tokushima Prefecture, Japan, and its peels are rich in phytochemicals, including phenolic compounds. Although it is expected that the extract of the C. sudachi peel elicits various beneficial physiological activities, the effect on the skin has not been investigated. In this study, we report that the aqueous extract from the peel of C. sudachi suppresses cell proliferation of the immortalized human keratinocyte cell line, HaCaT, and primary normal human epidermal keratinocytes. The extract of C. sudachi peel suppressed epidermal growth factor (EGF)-induced EGF receptor activation and tumor necrosis factor (TNF)-α-induced extracellular regulated kinase (ERK) 1/2 activation, which suggests that the extract exerts its inhibitory effect through inhibition of both the EGF receptor (EGFR) and its downstream molecules. Additionally, the extract of C. sudachi peel potentiated calcium-induced keratinocyte differentiation. These results suggest that the extract of C. sudachi peel may have beneficial effects against skin diseases that are characterized by hyperproliferation of epidermal keratinocytes, such as those seen in psoriasis and in cutaneous squamous cell carcinoma.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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Bioscience and Bioindustry