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ID 116486
著者
Abe, Shogo Tokushima University
Ueno, Misako Tokushima University
Nishitani, Mami Tokushima University
Sato, Takumi Tokushima University
Shimoda, Marie Matsuyama Co., Ltd.
Kanaoka, Hiroki Matsuyama Co., Ltd.
Nii, Yoshitaka Tokushima Prefectural Industrial Technology Center
Yamasaki, Hiroko Matsuyama Co., Ltd.
キーワード
citrus peel extract
keratinocyte
EGF–EGFR–ERK
cell proliferation and differentiation
資料タイプ
学術雑誌論文
抄録
Citrus sudachi is a well-known fruit in Tokushima Prefecture, Japan, and its peels are rich in phytochemicals, including phenolic compounds. Although it is expected that the extract of the C. sudachi peel elicits various beneficial physiological activities, the effect on the skin has not been investigated. In this study, we report that the aqueous extract from the peel of C. sudachi suppresses cell proliferation of the immortalized human keratinocyte cell line, HaCaT, and primary normal human epidermal keratinocytes. The extract of C. sudachi peel suppressed epidermal growth factor (EGF)-induced EGF receptor activation and tumor necrosis factor (TNF)-α-induced extracellular regulated kinase (ERK) 1/2 activation, which suggests that the extract exerts its inhibitory effect through inhibition of both the EGF receptor (EGFR) and its downstream molecules. Additionally, the extract of C. sudachi peel potentiated calcium-induced keratinocyte differentiation. These results suggest that the extract of C. sudachi peel may have beneficial effects against skin diseases that are characterized by hyperproliferation of epidermal keratinocytes, such as those seen in psoriasis and in cutaneous squamous cell carcinoma.
掲載誌名
Biomolecules
ISSN
2218273X
出版者
MDPI
10
10
開始ページ
1468
発行日
2020-10-21
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系