| ID | 109629 |
| Title Transcription | コウド シンコウ カンサイボウ ガン ニ タイスル ホウシャセン ヘイヨウ ドウチュウ カガク リョウホウ ノ ユウヨウセイ
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| Title Alternative | Efficacy and safety of concurrent chemotherapy and radiotherapy for advanced hepatocellular carcinoma with extensive portal vein tumor thrombus
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| Author |
Kobayashi, Naoto
The Post-graduate education Center, Tokushima University Hospital
Taniguchi, Tatsuya
Department of Gastroenterology and Oncology, Tokushima University Hospital
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Miyamoto, Yoshihiko
Department of Gastroenterology and Oncology, Tokushima University Hospital
Tanaka, Hiromichi
Department of Gastroenterology and Oncology, Tokushima University Hospital
Tanaka, Takahiro
Department of Gastroenterology and Oncology, Tokushima University Hospital
Takaba, Azusa
Department of Gastroenterology and Oncology, Tokushima University Hospital
Tomonari, Tetsu
Department of Gastroenterology and Oncology, Tokushima University Hospital
Tokushima University Educator and Researcher Directory
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Harada, Rie
Department of Gastroenterology and Oncology, Tokushima University Hospital
Sato, Momoko
Department of Gastroenterology and Oncology, Tokushima University Hospital
Sannomiya, Katsutaka
Department of Gastroenterology and Oncology, Tokushima University Hospital
Ikushima, Hitoshi
Department of Radiology, Tokushima University Hospital
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Tamaki, Katsuyoshi
Okubo Hospital
Takayama, Tetsuji
Department of Gastroenterology and Oncology, Tokushima University Hospital
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|
| Keywords | hepatocellular carcinoma
portal vein tumor thrombus
MPT
5‐FU
IFN
radiotherapy
|
| Content Type |
Journal Article
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| Description | OBJECTIVE : The purpose of this study is to assess the treatment outcomes and adverse effects of concurrent chemotherapy and radiotherapy for hepatocellular carcinoma with portal vein tumor thrombus.
METHODS : Twelve unresectable hepatocellular carcinoma patients with portal vein tumor thrombosis were treated using concurrent chemotherapy and radiation therapy. Four patients received transcatheter arterial chemoembolization using miriplatin-lipiodol suspension. Eight patients received interferon-α (IFN) and 5‐fluorouracil (5‐FU) combination therapy. The total radiation dose was 30‐50Gy. The response rate and overall survival and the toxicity were analyzed. RESULTS : Concurrent chemotherapy and radiotherapy was associated with a 50.0% objective response rate for primary tumors (miriplatin-lipiodol : 50.0%, IFN‐5FU : 50.0%). And a 66.7% objective response rate for portal vein tumor thrombus (miriplatin-lipiodol : 75.0%, IFN‐5FU : 62.5%). The median survival was 273 days (miriplatin-lipiodol : 273 days, IFN‐5FU : 262 days). Myelosuppression was observed in two patients, but no treatment-related deaths were observed. CONCLUSIONS : The present results suggest concurrent chemotherapy and radiotherapy is a practical and safe treatment option in hepatocellular carcinoma patients with extensive portal vein tumor thrombus. |
| Journal Title |
四国医学雑誌
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| ISSN | 00373699
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| NCID | AN00102041
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| Publisher | 徳島医学会
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| Volume | 69
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| Issue | 3-4
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| Start Page | 151
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| End Page | 156
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| Sort Key | 151
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| Published Date | 2013-08-25
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| FullText File | |
| language |
jpn
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| TextVersion |
Publisher
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| departments |
University Hospital
Medical Sciences
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