Facile synthesis of C-terminal peptide thioacids under mild conditions from N-sulfanylethylanilide peptides

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Use this link to cite this item : https://repo.lib.tokushima-u.ac.jp/111924

ID	111924
Author	Shimizu, Tatsuhiko Tokushima University Miyajima, Rin Tokushima University Sato, Kohei Tokushima University Sakamoto, Ken Tokushima University Naruse, Naoto Tokushima University Kita, Miku Tokushima University Shigenaga, Akira Tokushima University KAKEN Search Researchers Otaka, Akira Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords	C-Terminal peptide thioacids N-Sulfanylethylanilide peptide Hydrothiolysis Phosphate buffer
Content Type	Journal Article
Description	A facile procedure has been developed for the synthesis of C-terminal peptide thioacids under mild conditions. A series of N-sulfanylethylanilide peptides prepared using Fmoc-based solid-phase peptide synthesis were successfully converted to the corresponding thioacids via a hydrothiolysis reaction in a phosphate buffer with only trace epimerization of the C-terminal amino acid.
Journal Title	Tetrahedron
ISSN	00404020
NCID	AA00861787 AA11539786
Publisher	Elsevier Ltd.
Volume	72
Issue	7
Start Page	992
End Page	998
Published Date	2015-12-29
Rights	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID	306185
DOI (Published Version)	10.1016/j.tet.2015.12.070
URL ( Publisher's Version )	https://doi.org/10.1016/j.tet.2015.12.070
FullText File	tet_72_7_992.pdf 660 KB
language	eng
TextVersion	Author
departments	Pharmaceutical Sciences