| ID | 113941 |
| Author |
Nakao, Michiyasu
Tokushima University
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Nishikiori, Nanako
Tokushima University
Nakamura, Akihito
Tokushima University
Miyagi, Murasaki
Tokushima University
Shibata, Nao
Tokushima University
Kitaike, Syuji
Tokushima University
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Fukui, Makoto
Tokushima University
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Ito, Hiro-O
Tokushima University
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Sano, Shigeki
Tokushima University
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|
| Keywords | o-phthalaldehyde
isoindole
steric protection
isoindolin-1-one
|
| Content Type |
Journal Article
|
| Description | o-Phthalaldehyde (OPA) reacts with O-protected tris(hydroxyalkyl) aminomethanes in the presence of 1-propanethiol to afford a novel class of stable isoindoles. Steric protection provided by the bulkiness of C3-symmetric primary amines derived from tris(hydroxymethyl)aminomethane could be significant for the stabilization of 1-alkylthio-2-alkyl-substituted isoindoles derived from OPA. A plausible reaction mechanism is proposed to explain the formation of the isoindole and an isoindolin-1-one by-product.
|
| Journal Title |
SynOpen
|
| ISSN | 25099396
|
| Publisher | Georg Thieme Verlag Stuttgart
|
| Volume | 2
|
| Issue | 1
|
| Start Page | 50
|
| End Page | 57
|
| Published Date | 2018-02-20
|
| Rights | This article is published under the Creative Commons license CC BY-NC-ND (Attribution-NonCommercial-NoDerivatives)(https://creativecommons.org/licenses/by-nc-nd/4.0/)
|
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Pharmaceutical Sciences
Technical Support Department
Oral Sciences
|
