| ID | 113941 |
| 著者 |
Nishikiori, Nanako
Tokushima University
Nakamura, Akihito
Tokushima University
Miyagi, Murasaki
Tokushima University
Shibata, Nao
Tokushima University
|
| キーワード | o-phthalaldehyde
isoindole
steric protection
isoindolin-1-one
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | o-Phthalaldehyde (OPA) reacts with O-protected tris(hydroxyalkyl) aminomethanes in the presence of 1-propanethiol to afford a novel class of stable isoindoles. Steric protection provided by the bulkiness of C3-symmetric primary amines derived from tris(hydroxymethyl)aminomethane could be significant for the stabilization of 1-alkylthio-2-alkyl-substituted isoindoles derived from OPA. A plausible reaction mechanism is proposed to explain the formation of the isoindole and an isoindolin-1-one by-product.
|
| 掲載誌名 |
SynOpen
|
| ISSN | 25099396
|
| 出版者 | Georg Thieme Verlag Stuttgart
|
| 巻 | 2
|
| 号 | 1
|
| 開始ページ | 50
|
| 終了ページ | 57
|
| 発行日 | 2018-02-20
|
| 権利情報 | This article is published under the Creative Commons license CC BY-NC-ND (Attribution-NonCommercial-NoDerivatives)(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
出版社版
|
| 部局 |
薬学系
技術支援部
歯学系
|
