ID 111596
Title Alternative
RCT of Rokkaku Reishi essence
鹿角霊芝エキスの成人女性への二重盲検試験
Author
Yonei, Yoshikazu Doshisha University
Takahashi, Yoko Doshisha University
Takahashi, Hozumi Doshisha University
Watanabe, Miwako Maressia Garden Clinic
Mochizuki, Toshio Medical Urban Clinic
Keywords
Rokkaku Reishi
anti-aging medicine
safety
oxidative-stress marker
skin
Content Type
Journal Article
Description
A double-blind, randomized and placebo controlled study was carried out to examine the anti-aging efficacy and safety of Rokkaku Reishi in 22 overweight Japanese women (46.5±7.9 years old, BMI 26.8±2.7) consisting of 11 in the Analyte Group and 11 in the Placebo Group. Total cholesterol, LDL cholesterol and neutral fat values in the blood, which had been checked as background factors of the subjects, were mismatched, significantly higher respectively in the Analyte Group than in the Placebo Group. Evaluation of efficacy for lipid profiles was inevitable. In the Analyte Group the values of Hematocrit (–3.5%) and γ-GTP (–15.0%) significantly declined while HbA1c (2.3%) and K (5.4%) significantly increased after supplementation. The rate of increase of HbA1c in the Analyte Group was significantly higher than that in the Placebo Group. NK-cell activity showed no difference pre- and post-supplementation in either group. Oxidative-stress markers showed no significant difference pre- and post-supplementation for either group. A Common questionnaire on physical symptoms showed that the categories “Coughing and sputum” and “Grey hair” significantly declined after supplementation in the Analyte Group while no difference was found in the Placebo Group. For skin age scores measured using a Roboskinanalyzer, the scores for the categories “Noticeable pores”, “Large noticeable pores” and “Dusky noticeable pores” were significantly lower in the Analyte Group compared to the Placebo Group. A significant correlation was found between 8-OHdG in terms of its level, creatininecorrected value and generation rate, and the number of “Noticeable pores”. No adverse reaction was found during the study. These results suggest that the four weeks supplementation of Rokkaku Reishi showed favorable effects on skin condition.
Journal Title
ANTI-AGING MEDICINE
ISSN
18822762
Publisher
Japanese Society of Anti-Aging Medicine
Volume
4
Issue
1
Start Page
28
End Page
37
Published Date
2007-06-01
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences