YKL-40 secreted from adipose tissue inhibits degradation of type I collagen

Iwata, Takeo; Kuwajima, Masamichi; Sukeno, Akiko; Ishimaru, Naozumi; Hayashi, Yoshio; Wabitsch, Martin; Mizusawa, Noriko; Itakura, Mitsuo; Yoshimoto, Katsuhiko

doi:10.1016/j.bbrc.2009.08.024

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ID	109641
Author	Iwata, Takeo Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers Kuwajima, Masamichi Department of Clinical Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School Sukeno, Akiko Department of Clinical Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School Ishimaru, Naozumi Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers Hayashi, Yoshio Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers Wabitsch, Martin Division of Pediatric Endocrinology, Department of Pediatrics and Adolescent Medicine, University of Ulm Mizusawa, Noriko Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers Itakura, Mitsuo Division of Genetic Information, Institute for Genome Research, The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers Yoshimoto, Katsuhiko Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords	YKL-40 MMP-1 type I collagen adipose tissue macrophage preadipocyte
Content Type	Journal Article
Description	Obesity is considered a chronic low-grade inflammatory status and the stromal vascular fraction (SVF) cells of adipose tissue (AT) are considered a source of inflammation-related molecules. We identified YKL-40 as a major protein secreted from SVF cells in human visceral AT. YKL-40 expression levels in SVF cells from visceral AT were higher than in those from subcutaneous AT. Immunofluorescence staining revealed that YKL-40 was exclusively expressed in macrophages among SVF cells. YKL-40 purified from SVF cells inhibited the degradation of type I collagen, a major extracellular matrix of AT, by matrix metalloproteinase (MMP)-1 and increased rate of fibril formation of type I collagen. The expression of MMP-1 in preadipocytes and macrophages was enhanced by interaction between these cells. These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT, meanwhile, YKL-40 secreted from macrophages infiltrating into AT inhibits the type I collagen degradation.
Journal Title	Biochemical and Biophysical Research Communications
ISSN	0006291X
NCID	AA00564395
Volume	388
Issue	3
Start Page	511
End Page	516
Sort Key	511
Published Date	2009-10-23
Remark	© 2009 Elsevier Inc. All rights reserved. © 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID	210920
DOI (Published Version)	10.1016/j.bbrc.2009.08.024
URL ( Publisher's Version )	http://www.sciencedirect.com/science/article/pii/S0006291X09015770
FullText File	LID201602262002.pdf 1.03 MB
language	eng
TextVersion	Author
departments	Oral Sciences Institute of Advanced Medical Sciences