ID | 109641 |
Author |
Iwata, Takeo
Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Kuwajima, Masamichi
Department of Clinical Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Sukeno, Akiko
Department of Clinical Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Ishimaru, Naozumi
Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Hayashi, Yoshio
Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Wabitsch, Martin
Division of Pediatric Endocrinology, Department of Pediatrics and Adolescent Medicine, University of Ulm
Mizusawa, Noriko
Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Itakura, Mitsuo
Division of Genetic Information, Institute for Genome Research, The University of Tokushima
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Yoshimoto, Katsuhiko
Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Keywords | YKL-40
MMP-1
type I collagen
adipose tissue
macrophage
preadipocyte
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Content Type |
Journal Article
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Description | Obesity is considered a chronic low-grade inflammatory status and the stromal vascular fraction (SVF) cells of adipose tissue (AT) are considered a source of inflammation-related molecules. We identified YKL-40 as a major protein secreted from SVF cells in human visceral AT. YKL-40 expression levels in SVF cells from visceral AT were higher than in those from subcutaneous AT. Immunofluorescence staining revealed that YKL-40 was exclusively expressed in macrophages among SVF cells. YKL-40 purified from SVF cells inhibited the degradation of type I collagen, a major extracellular matrix of AT, by matrix metalloproteinase (MMP)-1 and increased rate of fibril formation of type I collagen. The expression of MMP-1 in preadipocytes and macrophages was enhanced by interaction between these cells. These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT, meanwhile, YKL-40 secreted from macrophages infiltrating into AT inhibits the type I collagen degradation.
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Journal Title |
Biochemical and Biophysical Research Communications
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ISSN | 0006291X
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NCID | AA00564395
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Volume | 388
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Issue | 3
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Start Page | 511
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End Page | 516
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Sort Key | 511
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Published Date | 2009-10-23
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Remark | © 2009 Elsevier Inc. All rights reserved.
© 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Author
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departments |
Oral Sciences
Institute of Advanced Medical Sciences
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