ID 109641
著者
岩田, 武男 Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
クワジマ, マサミチ Department of Clinical Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
スケノ, アキコ Department of Clinical Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
石丸, 直澄 Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
林, 良夫 Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Wabitsch, Martin Division of Pediatric Endocrinology, Department of Pediatrics and Adolescent Medicine, University of Ulm
水澤, 典子 Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
板倉, 光夫 Division of Genetic Information, Institute for Genome Research, The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
吉本, 勝彦 Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
YKL-40
MMP-1
type I collagen
adipose tissue
macrophage
preadipocyte
資料タイプ
学術雑誌論文
抄録
Obesity is considered a chronic low-grade inflammatory status and the stromal vascular fraction (SVF) cells of adipose tissue (AT) are considered a source of inflammation-related molecules. We identified YKL-40 as a major protein secreted from SVF cells in human visceral AT. YKL-40 expression levels in SVF cells from visceral AT were higher than in those from subcutaneous AT. Immunofluorescence staining revealed that YKL-40 was exclusively expressed in macrophages among SVF cells. YKL-40 purified from SVF cells inhibited the degradation of type I collagen, a major extracellular matrix of AT, by matrix metalloproteinase (MMP)-1 and increased rate of fibril formation of type I collagen. The expression of MMP-1 in preadipocytes and macrophages was enhanced by interaction between these cells. These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT, meanwhile, YKL-40 secreted from macrophages infiltrating into AT inhibits the type I collagen degradation.
掲載誌名
Biochemical and Biophysical Research Communications
ISSN
0006291X
cat書誌ID
AA00564395
388
3
開始ページ
511
終了ページ
516
並び順
511
発行日
2009-10-23
備考
© 2009 Elsevier Inc. All rights reserved.
© 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出典
Biochemical and Biophysical Research Communications (2009) Volume 388 Issue 3 P.511–516 (doi:10.1016/j.bbrc.2009.08.024)
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系
先端酵素学研究所