ID | 109717 |
Title Alternative | 早産児では尿中アンジオテンシノーゲンの排泄量が増加している
Urinary angiotensinogen during renal development in neonates
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Author |
Urushihara, Maki
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Nakagawa, Ryuji
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Saijo, Takahiko
The University of Tokushima
Kagami, Shoji
The University of Tokushima
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Keywords | Renin–angiotensin system
Neonates
Renal development
Gestational age
Preterm
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Content Type |
Thesis or Dissertation
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Description | Background
All components of the renin-angiotensin system (RAS) are abundantly synthesized in the developing kidney, suggesting that the RAS plays an important role in renal development. To examine this system in human neonates, we measured urinary angiotensinogen levels in preterm and full-term neonates, and examined the relationship between urinary angiotensinogen levels and gestational age. Methods Urine and plasma samples were collected from 20 preterm and 18 full-term neonates at birth. Angiotensinogen levels were measured using enzyme-linked immunosorbent assay. Results Plasma angiotensinogen concentrations were not increased in preterm neonates compared to that in full-term neonates (P = 0.7288). However, the urinary angiotensinogen-to-creatinine ratio was significantly higher in preterm neonates compared to that in full-term neonates (P = 0.0011). Importantly, the urinary angiotensinogen-to-creatinine ratio dropped significantly with increasing gestational age (P = 0.0010), whereas the plasma angiotensinogen concentration was not correlated with gestational age (P = 0.7814). Conclusions These results suggest that urinary angiotensinogen levels may indicate the involvement of intrarenal RAS activation in prenatal renal development. |
Journal Title |
Clinical and Experimental Nephrology
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ISSN | 13421751
14377799
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NCID | AA11619535
AA11126935
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Publisher | Japanese Society of Nephrology|Springer nature
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Volume | 19
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Issue | 2
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Start Page | 293
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End Page | 297
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Published Date | 2014-05-03
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Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606211001.pdf 論文本文 : LID201703211001.pdf 本論文は, 著者Masashi Suzueの学位論文として提出され, 学位審査・授与の対象となっている。 The final publication is available at Springer via https://doi.org/10.1007/s10157-014-0977-y |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第2901号
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Diploma Number | 甲医第1275号
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Granted Date | 2016-03-23
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
University Hospital
Medical Sciences
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