ID | 114034 |
Title Alternative | Definite ECRS diagnosis with systemic steroid
|
Author |
Fujimoto, Chisa
Yoshinogawa Medical Center|Tokushima Municipal Hospital
Takaishi, Shizuka
Tokushima Municipal Hospital
Kawata, Ikuji
Yoshinogawa Medical Center
Kitamura, Yoshiaki
The University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Takeda, Noriaki
The University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
Keywords | eosinophilic chronic rhinosinusitis (ECRS)
chronic rhinosinusitis with nasal polyps
preoperative systemic steroids
endoscopic sinus surgery (ESS)
Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC)
|
Content Type |
Journal Article
|
Description | According to JESREC criteria, definite eosinophilic chronic rhinosinusitis (ECRS) is postoperatively diagnosed based on over 70 eosinophils in high power magnification fields of the resected nasal polyps in patients with probable ECRS. Preoperative systemic administration with steroid is a standard practice, because it reduced intraoperative bleeding during endoscopic sinus surgery (ESS) in patients with ECRS. However, it was recently reported that systemic administration with steroid decreased the number of eosinophils in the nasal polyps, leading to a false negative diagnosis of definite ECRS. To overcome the risk, we have adopted short-term pre-operative systemic administration with low-dose of steroid and examined if our steroid administration makes a false-negative diagnosis. We performed a retrospective chart review of 42 patients with probable ECRS. Eleven patients were administered with 0.5 mg of bethametasone for 7 days before ESS, and other 31 patients were not administered. The average number of eosinophils in nasal polyps in patients who were administered with steroid was 188 ± 167, which was not different from 199 ± 149 in the patients who were not administered. These findings suggest that short-term preoperative administration with low-dose of steroid has few risk of a false-negative diagnosis of definite ECRS.
|
Journal Title |
The Journal of Medical Investigation
|
ISSN | 13496867
13431420
|
NCID | AA12022913
AA11166929
|
Publisher | Tokushima University Faculty of Medicine
|
Volume | 66
|
Issue | 3-4
|
Start Page | 233
|
End Page | 236
|
Sort Key | 233
|
Published Date | 2019-08
|
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
Publisher
|
departments |
University Hospital
Medical Sciences
|