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ID 115970
Title Alternative
リンパ節のPET/CTによるSUVmaxに重み付け係数を乗じてCECTの最大短径を加えた新しいcombined indexによる舌癌の臨床的N0症例の潜在的リンパ節転移の評価
Combined index to evaluate N0 neck
Author
Kanamura, Ryo Tokushima University|Osaka International Cancer Institute Tokushima University Educator and Researcher Directory
Suzuki, Motoyuki Osaka International Cancer Institute|Osaka University
Otozai, Shinji Osaka International Cancer Institute
Yoshii, Tadashi Osaka International Cancer Institute
Okamoto, Hidehiko International University of Health and Welfare
Abe, Koji Tokushima University KAKEN Search Researchers
Fujii, Takashi Tokushima University
Keywords
Tongue cancer
lymph node metastasis
clinical N0 neck
occult nodal metastasis
PET/CT
Content Type
Thesis or Dissertation
Description
To predict occult nodal metastasis in clinical N0 patients with tongue cancer, we developed combined index (CI) : SUVmax of the largest lymph node in PET/CT by weighting coefficient plus its maximum minor axis (< 10 mm) in contrast-enhanced CT (CECT). In this retrospective study, 57 clinical N0 patients with tongue cancer, who underwent elective supraomohyoid neck dissection at cervical levels of I-III were enrolled. The cutoff value of SUVmax of 2.0 obtained using receiver operating characteristic (ROC) analysis predicted the postoperative positive cervical levels containing metastatic lymph nodes from clinical N0 cervical levels in tongue cancer patients with a sensitivity of 54.5% and a specificity of 78.2%. The cutoff value of CI with weighting coefficient of 1.5 obtained using ROC analysis was 9.8 at the maximum area under the curve of 0.750. The cutoff value of 9.8 predicted the postoperative positive cervical levels containing metastatic lymph nodes from clinical N0 cervical levels in tongue cancer patients with a sensitivity of 68.2% and a specificity of 81.5%. These findings suggest that CI of functional PET/CT and morphological CECT components might improve the diagnostic performance of occult nodal metastasis to select clinical N0 patients with tongue cancer preferable for elective neck dissection.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
68
Issue
1-2
Start Page
154
End Page
158
Sort Key
154
Published Date
2021-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Ryo Kanamuraの学位論文として提出され,学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3487号
Diploma Number
甲医第1491号
Granted Date
2021-03-17
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences