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ID 114965
Koyama, Teruhide Kyoto Prefectural University of Medicine
Matsui, Daisuke Kyoto Prefectural University of Medicine
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Tanaka, Keitaro Saga University
Oze, Isao Aichi Cancer Center Research Institute
Hamajima, Nobuyuki Nagoya University
Wakai, Kenji Nagoya University
Okada, Rieko Nagoya University
Mikami, Haruo Chiba Cancer Center
Shimatani, Keiichi Kagoshima University
Hirata, Akie Kyushu University
Takashima, Naoyuki Shiga University of Medical Science
Suzuki, Sadao Nagoya City University
Nagata, Chisato Gifu University
Kubo, Michiaki RIKEN
Tanaka, Hideo Aichi Cancer Center Research Institute
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Journal Article
Hyperuricaemia is an undisputed and highly predictive biomarker for cardiovascular risk. SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide polymorphisms that decrease uric acid levels. Therefore, we examined SLC17A1 polymorphisms (rs1165196, rs1179086 and rs3757131), which might suppress cardiovascular risk factors and that are involved in liver functioning, via a large-scale pooled analysis of the Japanese general population in a cross-sectional study. Using data from the Japan Multi-Institutional Collaborative Cohort Study, we identified 1842 participants of both sexes, 35–69-years-old, having the requisite data and analysed their SLC17A1 genotypes. In men, logistic regression analyses revealed that minor alleles in SLC17A1 polymorphisms (rs1165196 and rs3757131) were associated with a low-/high-density lipoprotein cholesterol ratio >2.0 (rs1165196: odds ratio [OR], 0.703; 95% confidence interval [CI], 0.536–0.922; rs3757131: OR, 0.658; 95% CI, 0.500–0.866) and with homocysteine levels of >10.0 nmol/mL (rs1165196: OR, 0.544; 95% CI, 0.374–0.792; rs3757131: OR, 0.509; 95% CI, 0.347–0.746). Therefore, these polymorphisms had dominant negative effects on cholesterol homeostasis and hyperhomocysteinaemia, in men, independent of alcohol consumption, physical activity, or daily energy and nutrition intake. Thus, genetic variants of SLC17A1 are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men.
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Scientific Reports
Springer Nature
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Medical Sciences