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ID 114965
著者
Koyama, Teruhide Kyoto Prefectural University of Medicine
Matsui, Daisuke Kyoto Prefectural University of Medicine
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Tanaka, Keitaro Saga University
Oze, Isao Aichi Cancer Center Research Institute
Hamajima, Nobuyuki Nagoya University
Wakai, Kenji Nagoya University
Okada, Rieko Nagoya University
Mikami, Haruo Chiba Cancer Center
Shimatani, Keiichi Kagoshima University
Hirata, Akie Kyushu University
Takashima, Naoyuki Shiga University of Medical Science
Suzuki, Sadao Nagoya City University
Nagata, Chisato Gifu University
Kubo, Michiaki RIKEN
Tanaka, Hideo Aichi Cancer Center Research Institute
資料タイプ
学術雑誌論文
抄録
Hyperuricaemia is an undisputed and highly predictive biomarker for cardiovascular risk. SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide polymorphisms that decrease uric acid levels. Therefore, we examined SLC17A1 polymorphisms (rs1165196, rs1179086 and rs3757131), which might suppress cardiovascular risk factors and that are involved in liver functioning, via a large-scale pooled analysis of the Japanese general population in a cross-sectional study. Using data from the Japan Multi-Institutional Collaborative Cohort Study, we identified 1842 participants of both sexes, 35–69-years-old, having the requisite data and analysed their SLC17A1 genotypes. In men, logistic regression analyses revealed that minor alleles in SLC17A1 polymorphisms (rs1165196 and rs3757131) were associated with a low-/high-density lipoprotein cholesterol ratio >2.0 (rs1165196: odds ratio [OR], 0.703; 95% confidence interval [CI], 0.536–0.922; rs3757131: OR, 0.658; 95% CI, 0.500–0.866) and with homocysteine levels of >10.0 nmol/mL (rs1165196: OR, 0.544; 95% CI, 0.374–0.792; rs3757131: OR, 0.509; 95% CI, 0.347–0.746). Therefore, these polymorphisms had dominant negative effects on cholesterol homeostasis and hyperhomocysteinaemia, in men, independent of alcohol consumption, physical activity, or daily energy and nutrition intake. Thus, genetic variants of SLC17A1 are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men.
掲載誌名
Scientific Reports
ISSN
20452322
出版者
Springer Nature
5
開始ページ
15888
発行日
2015-11-03
権利情報
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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言語
eng
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出版社版
部局
医学系