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ID 117242
Title Alternative
Sedentary Time and All-Cause Mortality
Author
Koyama, Teruhide Kyoto Prefectural University of Medicine
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Kuriyama, Nagato Kyoto Prefectural University of Medicine|Shizuoka Graduate University of Public Health
Tomida, Satomi Kyoto Prefectural University of Medicine
Yoshida, Tamami Kyoto Prefectural University of Medicine
Uehara, Ritei Kyoto Prefectural University of Medicine
Tanaka, Keitaro Saga University
Hara, Megumi Saga University
Hishida, Asahi Nagoya University
Okada, Rieko Nagoya University
Kubo, Yoko Nagoya University
Oze, Isao Aichi Cancer Center Research Institute
Koyanagi, Yuriko N. Aichi Cancer Center Research Institute
Mikami, Haruo Chiba Cancer Center Research Institute
Nakamura, Yohko Chiba Cancer Center Research Institute
Shimoshikiryo, Ippei Kagoshima University
Takezaki, Toshiro Kagoshima University
Suzuki, Sadao Nagoya City University
Otani, Takahiro Nagoya City University
Kuriki, Kiyonori University of Shizuoka
Takashima, Naoyuki Kindai University|Shiga University of Medical Science
Kadota, Aya Shiga University of Medical Science
Ikezaki, Hiroaki Kyushu University
Murata, Masayuki Kyushu University
Takeuchi, Kenji Nagoya University
Wakai, Kenji Nagoya University
Keywords
all-cause mortality
diabetes mellitus
dyslipidemia
hypertension
sedentary time
Content Type
Journal Article
Description
BACKGROUND: This study aimed to determine the association between sedentary time and mortality with regard to leisure‐time physical activity with or without cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus.
METHODS AND RESULTS: Using data from the J‐MICC (Japan Multi‐Institutional Collaborative Cohort) Study, 64 456 participants (29 022 men, 35 434 women) were analyzed. Hazard ratios (HRs) and 95% CIs were used to characterize the relative risk of all‐cause mortality to evaluate its association with sedentary time (categorical variables: <5, 5 to <7, 7 to <9, ≥9 h/d and 2‐hour increments in exposure) according to the self‐reported hypertension, dyslipidemia, and diabetes mellitus using a Cox proportional hazards model. A total of 2257 participants died during 7.7 years of follow‐up. The corresponding HRs for each 2‐hour increment in sedentary time among participants with all factors, no factors, hypertension, dyslipidemia, and diabetes mellitus were 1.153 (95% CI, 1.114–1.194), 1.125 (95% CI, 1.074–1.179), 1.202 (95% CI, 1.129–1.279), 1.176 (95% CI, 1.087–1.273), and 1.272 (95% CI, 1.159–1.396), respectively. Furthermore, when analyzed according to the combined different factors (hypertension, dyslipidemia, and diabetes mellitus), HRs increased with each additional factor, and participants reporting all 3 conditions had the highest HR of 1.417 (95% CI, 1.162–1.728) independently of leisure‐time metabolic equivalents.
CONCLUSIONS: The association between sedentary time and increased mortality is stronger among patients with hypertension, dyslipidemia, and diabetes mellitus regardless of leisure‐time physical activity in a large Japanese population.
Journal Title
Journal of the American Heart Association
ISSN
20479980
Publisher
The American Heart Association|Wiley
Volume
10
Issue
13
Start Page
e018293
Published Date
2021-06-14
Rights
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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language
eng
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departments
Medical Sciences