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ID 113791
Title Alternative
腎臓の発達過程である新生児においてアンジオテンシノーゲンの発現は増強している
Angiotensinogen expression in neonates
Author
Shono, Miki Tokushima University
Watanabe, Noriko Tokushima University
Keywords
Angiotensinogen
renin-angiotensin system
kidney development
neonates
Content Type
Thesis or Dissertation
Description
Background
We recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with intrarenal renin-angiotensin system (RAS) status during kidney development.
Methods
We prospectively recruited neonates born at our hospital and healthy children with minor glomerular abnormalities between April 2013 and March 2017. We measured neonatal plasma and urinary AGT levels at birth and one year later and assessed renal AGT expression in kidney tissues from neonates and healthy children using immunohistochemical (IHC) analysis.
Results
Fifty-four neonates and eight children were enrolled. Although there were no changes in plasma AGT levels, urinary AGT levels were significantly decreased one year after birth. Urinary AGT levels at birth were inversely correlated with gestational age, and urinary AGT levels at birth and one year later were inversely correlated with estimated glomerular filtration rate one year after birth. IHC analysis showed that renal AGT expression in neonates was higher than that in healthy children and inversely correlated with gestational age.
Conclusions
Enhanced AGT expression and urinary AGT excretion may reflect intrarenal RAS activation associated with kidney development in utero.
Journal Title
Clinical and Experimental Nephrology
ISSN
13421751
14377799
NCID
AA11126935
Publisher
Springer Singapore|Japanese Society of Nephrology
Volume
23
Issue
4
Start Page
537
End Page
543
Published Date
2018-10-23
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Miki Shonoの学位論文として提出され,学位審査・授与の対象となっている。
This is a post-peer-review, pre-copyedit version of an article published in Clinical and Experimental Nephrology. The final authenticated version is available online at: https://doi.org/10.1007/s10157-018-1662-3
Rights
© Japanese Society of Nephrology 2018
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3334号
Diploma Number
甲医第1428号
Granted Date
2019-09-26
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences