Angiotensinogen expression in neonates
Shono, Miki Tokushima University
Urushihara, Maki Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Suga, Kenichi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Watanabe, Noriko Tokushima University
Nakagawa, Ryuji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kagami, Shoji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Thesis or Dissertation
We recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with intrarenal renin-angiotensin system (RAS) status during kidney development.
We prospectively recruited neonates born at our hospital and healthy children with minor glomerular abnormalities between April 2013 and March 2017. We measured neonatal plasma and urinary AGT levels at birth and one year later and assessed renal AGT expression in kidney tissues from neonates and healthy children using immunohistochemical (IHC) analysis.
Fifty-four neonates and eight children were enrolled. Although there were no changes in plasma AGT levels, urinary AGT levels were significantly decreased one year after birth. Urinary AGT levels at birth were inversely correlated with gestational age, and urinary AGT levels at birth and one year later were inversely correlated with estimated glomerular filtration rate one year after birth. IHC analysis showed that renal AGT expression in neonates was higher than that in healthy children and inversely correlated with gestational age.
Enhanced AGT expression and urinary AGT excretion may reflect intrarenal RAS activation associated with kidney development in utero.
Clinical and Experimental Nephrology
Springer Singapore|Japanese Society of Nephrology
This is a post-peer-review, pre-copyedit version of an article published in Clinical and Experimental Nephrology. The final authenticated version is available online at: https://doi.org/10.1007/s10157-018-1662-3
© Japanese Society of Nephrology 2018
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|MEXT report number||
Doctor of Medical Science