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ID 113791
タイトル別表記
腎臓の発達過程である新生児においてアンジオテンシノーゲンの発現は増強している
Angiotensinogen expression in neonates
著者
庄野, 実希 徳島大学大学院医科学教育部(医学専攻)
Watanabe, Noriko Tokushima University
キーワード
Angiotensinogen
renin-angiotensin system
kidney development
neonates
資料タイプ
学位論文
抄録
Background
We recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with intrarenal renin-angiotensin system (RAS) status during kidney development.
Methods
We prospectively recruited neonates born at our hospital and healthy children with minor glomerular abnormalities between April 2013 and March 2017. We measured neonatal plasma and urinary AGT levels at birth and one year later and assessed renal AGT expression in kidney tissues from neonates and healthy children using immunohistochemical (IHC) analysis.
Results
Fifty-four neonates and eight children were enrolled. Although there were no changes in plasma AGT levels, urinary AGT levels were significantly decreased one year after birth. Urinary AGT levels at birth were inversely correlated with gestational age, and urinary AGT levels at birth and one year later were inversely correlated with estimated glomerular filtration rate one year after birth. IHC analysis showed that renal AGT expression in neonates was higher than that in healthy children and inversely correlated with gestational age.
Conclusions
Enhanced AGT expression and urinary AGT excretion may reflect intrarenal RAS activation associated with kidney development in utero.
掲載誌名
Clinical and Experimental Nephrology
ISSN
13421751
14377799
cat書誌ID
AA11126935
出版者
Springer Singapore|Japanese Society of Nephrology
23
4
開始ページ
537
終了ページ
543
発行日
2018-10-23
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Miki Shonoの学位論文として提出され,学位審査・授与の対象となっている。
This is a post-peer-review, pre-copyedit version of an article published in Clinical and Experimental Nephrology. The final authenticated version is available online at: https://doi.org/10.1007/s10157-018-1662-3
権利情報
© Japanese Society of Nephrology 2018
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3334号
学位記番号
甲医第1428号
学位授与年月日
2019-09-26
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系