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ID 116052
Title Alternative
周閉経期および閉経期ラットにおける体重、摂食量、脂肪細胞および生化学検査項目に対するオキシトシンの末梢投与の影響
Effects of oxytocin in postmenopausal rats
Author
Erdenebayar, Otgontsetseg Tokushima University
Kasai, Kana Tokushima University
Keywords
Oxytocin
peri- and postmenopause
metabolic function
feeding function
Menopause
Body weight
Food intake
Adipocyte
Content Type
Thesis or Dissertation
Description
Recent studies have revealed that the administration of oxytocin has beneficial effects on the regulation of body weight, food intake, and metabolic functions, especially in obese individuals. Obesity is common in women after the menopause and drives many components of metabolic syndrome. Weight gain in menopausal women has been frequently reported. Although obesity and associated metabolic disorders are frequently observed in peri- and postmenopausal women, there are few medical interventions for these conditions. In this study, we evaluated the effects of chronic oxytocin administration on appetite, body weight, and fat mass in peri- and postmenopausal female rats. Sixteen naturally premenopausal or menopausal rats were intraperitoneally injected with oxytocin (1,000 μg/day) for 12 days. The daily changes in their body weight and food intake were measured at the same time as the oxytocin and vehicle injections. Intraperitoneally administering oxytocin for 12 days significantly reduced food intake, body weight, and visceral adipocyte size. In addition, oxytocin administration caused reductions in serum triglyceride and low-density lipoprotein-cholesterol levels, while it did not disturb hepatic or renal functions or locomotor activity. This is the first study to show the effects of oxytocin on the metabolic and feeding functions of peri- and postmenopausal female rats. Oxytocin might be a useful treatment for metabolic disorders caused by the menopause or aging.
Journal Title
Endocrine Journal
ISSN
09188959
13484540
Publisher
The Japan Endocrine Society
Volume
68
Issue
1
Start Page
7
End Page
16
Published Date
2021-1-28
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Otgontsetseg Erdenebayarの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© The Japan Endocrine Society
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3499号
Diploma Number
甲医第1485号
Granted Date
2021-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital