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ID 116052
タイトル別表記
周閉経期および閉経期ラットにおける体重、摂食量、脂肪細胞および生化学検査項目に対するオキシトシンの末梢投与の影響
Effects of oxytocin in postmenopausal rats
著者
エレデネバヤル, オトゴンツェツェグ 徳島大学大学院医科学教育部(医学専攻)
Kasai, Kana Tokushima University
キーワード
Oxytocin
peri- and postmenopause
metabolic function
feeding function
Menopause
Body weight
Food intake
Adipocyte
資料タイプ
学位論文
抄録
Recent studies have revealed that the administration of oxytocin has beneficial effects on the regulation of body weight, food intake, and metabolic functions, especially in obese individuals. Obesity is common in women after the menopause and drives many components of metabolic syndrome. Weight gain in menopausal women has been frequently reported. Although obesity and associated metabolic disorders are frequently observed in peri- and postmenopausal women, there are few medical interventions for these conditions. In this study, we evaluated the effects of chronic oxytocin administration on appetite, body weight, and fat mass in peri- and postmenopausal female rats. Sixteen naturally premenopausal or menopausal rats were intraperitoneally injected with oxytocin (1,000 μg/day) for 12 days. The daily changes in their body weight and food intake were measured at the same time as the oxytocin and vehicle injections. Intraperitoneally administering oxytocin for 12 days significantly reduced food intake, body weight, and visceral adipocyte size. In addition, oxytocin administration caused reductions in serum triglyceride and low-density lipoprotein-cholesterol levels, while it did not disturb hepatic or renal functions or locomotor activity. This is the first study to show the effects of oxytocin on the metabolic and feeding functions of peri- and postmenopausal female rats. Oxytocin might be a useful treatment for metabolic disorders caused by the menopause or aging.
掲載誌名
Endocrine Journal
ISSN
09188959
13484540
出版者
The Japan Endocrine Society
68
1
開始ページ
7
終了ページ
16
発行日
2021-1-28
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Otgontsetseg Erdenebayarの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© The Japan Endocrine Society
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3499号
学位記番号
甲医第1485号
学位授与年月日
2021-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院