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ID 113938
Author
Tsuji, Shunsuke Tokushima University
Keywords
erythrochelin
rhodotorulic acid
siderophore
2,5-diketopiperazine
electrospray ionization mass spectrometry
Content Type
Journal Article
Description
Erythrochelin, a hydroxamate-type siderophore produced by Saccharopolyspora erythraea, is synthesized for the first time. A key building block of erythrochelin containing the 2,5-diketopiperazine ring is prepared by intramolecular cyclization of the corresponding dipeptide precursor derived from two kinds of protected δ-N-hydroxy-L-ornithines. Consecutive condensation of the building block with protected D-serine and protected δ-N-hydroxy-D-ornithine, followed by deprotection, furnishes erythrochelin.
Journal Title
Synthesis
ISSN
00397881
1437210X
NCID
AA00855740
Publisher
Georg Thieme Verlag Stuttgart
Volume
48
Issue
23
Start Page
4149
End Page
4154
Published Date
2016-08-24
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences
Technical Support Department