Inaba, Hiroshi Tottori University
Uemura, Akihito Tottori University
Morishita, Kazushi Tottori University
Kohiki, Taiki Tokushima University
Otaka, Akira Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Matsuura, Kazunori Tottori University
Light-driven nano/micromotors are attracting much attention, not only as molecular devices but also as components of bioinspired robots. In nature, several pathogens such as Listeria use actin polymerisation machinery for their propulsion. Despite the development of various motors, it remains challenging to mimic natural systems to create artificial motors propelled by fibre formation. Herein, we report the propulsion of giant liposomes driven by light-induced peptide nanofibre growth on their surface. Peptide-DNA conjugates connected by a photocleavage unit were asymmetrically introduced onto phase-separated giant liposomes. Ultraviolet (UV) light irradiation cleaved the conjugates and released peptide units, which self-assembled into nanofibres, driving the translational movement of the liposomes. The velocity of the liposomes reflected the rates of the photocleavage reaction and subsequent fibre formation of the peptide-DNA conjugates. These results showed that chemical design of the light-induced peptide nanofibre formation is a useful approach to fabricating bioinspired motors with controllable motility.
Supplementary Information : srep_8_6243_s1.docx
Supplementary Video : srep_8_6243_s2.mp4
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srep_8_6243.pdf 3.23 MB
srep_8_6243_s1.docx 3.52 MB
srep_8_6243_s2.mp4 15.8 MB