Ogura, Keiji The University of Tokushima
Hirakawa, Hiroko The University of Tokushima
Yamamoto, Jun The University of Tokushima
Ebisuno, Koji The University of Tokushima
Ishizawa, Keisuke The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tsuchiya, Koichiro The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Otaka, Akira The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
peptide bond cleavage
Utilization of a hypoxia-responsive amino acid is indispensable in the preparation of hypoxic tumor-specific peptidyl prodrugs. Bioreduction of a nitro group is among the most attractive triggering reactions in the hypoxia-responsive prodrugs. In this paper, design and synthesis of a reduction-responsive amino acid that induces peptide bond cleavage after reduction of the nitro group are described. Application to hypoxia-responsive peptide bond cleavage system is also reported.
WILEY‐VCH Verlag GmbH & Co. KGaA
This is the peer reviewed version of the following article: Shigenaga, A. , Ogura, K. , Hirakawa, H. , Yamamoto, J. , Ebisuno, K. , Miyamoto, L. , Ishizawa, K. , Tsuchiya, K. and Otaka, A. (2012), Development of a Reduction‐Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells. ChemBioChem, 13: 968-971. doi:10.1002/cbic.201200141, which has been published in final form at https://doi.org/10.1002/cbic.201200141. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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