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ID 116268
Author
Shikama, Yosuke National Center for Geriatrics and Gerontology KAKEN Search Researchers
Kurosawa, Mie National Center for Geriatrics and Gerontology
Furukawa, Masae National Center for Geriatrics and Gerontology
Matsushita, Kenji National Center for Geriatrics and Gerontology
Keywords
dry eye
adiponectin
peroxisome proliferator-activated receptor gamma
senescence-associated T cells
aging
Content Type
Journal Article
Description
Common age-related changes in the human eye contribute to the development of dry eye, including decreases in aqueous tear production. Although the infiltration of lymphocytes into the lacrimal glands occurs with age, age-related increases in tear production have also been observed in mice; however, the mechanisms underlying this increase remain unclear. We herein demonstrated that increases in tear production were not dependent on body weight gain or systemic conditions, such as insulin resistance, using aged mice and high-fat diet-fed mice. The results obtained also showed that senescence-associated T (SA-T) cells accumulated in the lacrimal glands of aged mice, particularly females. Expression levels of the nuclear transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) in whole lacrimal glands and epithelial cells isolated from lacrimal glands were significantly higher in aged mice than in young mice. The expression levels of adiponectin and one of its receptors, AdipoR2, also increased in the lacrimal glands of aged mice, but not in those of high-fat diet-fed mice. Collectively, the present results indicate that PPARγ and adiponectin-mediated signaling contribute to age-related increases in tear production in mice and have potential as therapeutic targets for the treatment of dry eye in humans.
Journal Title
Aging
ISSN
19454589
Publisher
Impact Journals
Volume
11
Issue
19
Start Page
8329
End Page
8346
Published Date
2019-10-08
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0)(https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published Version)
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language
eng
TextVersion
Publisher
departments
University Hospital
Oral Sciences