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ID 116268
著者
四釜, 洋介 National Center for Geriatrics and Gerontology KAKEN研究者をさがす
Kurosawa, Mie National Center for Geriatrics and Gerontology
Furukawa, Masae National Center for Geriatrics and Gerontology
Matsushita, Kenji National Center for Geriatrics and Gerontology
キーワード
dry eye
adiponectin
peroxisome proliferator-activated receptor gamma
senescence-associated T cells
aging
資料タイプ
学術雑誌論文
抄録
Common age-related changes in the human eye contribute to the development of dry eye, including decreases in aqueous tear production. Although the infiltration of lymphocytes into the lacrimal glands occurs with age, age-related increases in tear production have also been observed in mice; however, the mechanisms underlying this increase remain unclear. We herein demonstrated that increases in tear production were not dependent on body weight gain or systemic conditions, such as insulin resistance, using aged mice and high-fat diet-fed mice. The results obtained also showed that senescence-associated T (SA-T) cells accumulated in the lacrimal glands of aged mice, particularly females. Expression levels of the nuclear transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) in whole lacrimal glands and epithelial cells isolated from lacrimal glands were significantly higher in aged mice than in young mice. The expression levels of adiponectin and one of its receptors, AdipoR2, also increased in the lacrimal glands of aged mice, but not in those of high-fat diet-fed mice. Collectively, the present results indicate that PPARγ and adiponectin-mediated signaling contribute to age-related increases in tear production in mice and have potential as therapeutic targets for the treatment of dry eye in humans.
掲載誌名
Aging
ISSN
19454589
出版者
Impact Journals
11
19
開始ページ
8329
終了ページ
8346
発行日
2019-10-08
権利情報
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0)(https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
歯学系