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ID 118299
Author
Yoshida, Hideyuki RIKEN
Keywords
mTEC
Aire
single-cell analysis
heterogeneity
tissue-restricted antigens
Content Type
Journal Article
Description
The thymus is a highly specialized organ that plays an indispensable role in the establishment of self-tolerance, a process characterized by the “education” of developing T-cells. To provide competent T-cells tolerant to self-antigens, medullary thymic epithelial cells (mTECs) orchestrate negative selection by ectopically expressing a wide range of genes, including various tissue-restricted antigens (TRAs). Notably, recent advancements in the high-throughput single-cell analysis have revealed remarkable heterogeneity in mTECs, giving us important clues for dissecting the mechanisms underlying TRA expression. We overview how recent single-cell studies have furthered our understanding of mTECs, with a focus on the role of Aire in inducing mTEC heterogeneity to encompass TRAs.
Journal Title
Frontiers in Immunology
ISSN
16643224
Publisher
Frontiers Media S.A.
Volume
14
Start Page
1176450
Published Date
2023-05-03
Rights
© 2023 Matsumoto, Yoshida, Tsuneyama, Oya and Matsumoto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI (Published Version)
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language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences