Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice

Sakai, Tohru; Shuto, Emi; Taki, Tomoyo; Imamura, Honami; Kioka, Miku; Nakamoto, Akiko; Mizoguchi, Seiji; Amano, Shouko; Kawano, Yukari; Nakamoto, Mariko; Tsutumi, Rie; Hosaka, Toshio

doi:10.2152/jmi.59.95

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ID	106005
Author	Sakai, Tohru Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers Shuto, Emi Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School KAKEN Search Researchers Taki, Tomoyo Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Imamura, Honami Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Kioka, Miku Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Nakamoto, Akiko Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers Mizoguchi, Seiji Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Amano, Shouko Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Kawano, Yukari Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Nakamoto, Mariko Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers Tsutumi, Rie Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School Hosaka, Toshio Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
Keywords	cathepsin E dendritic cells MHC class II NC/Nga mice
Content Type	Journal Article
Description	NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)- immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.
Journal Title	The journal of medical investigation : JMI
ISSN	13431420
NCID	AA11166929
Volume	59
Issue	1-2
Start Page	95
End Page	101
Sort Key	95
Published Date	2012-02
EDB ID	269288
DOI (Published Version)	10.2152/jmi.59.95
URL ( Publisher's Version )	https://doi.org/10.2152/jmi.59.95
FullText File	LID201402042005.pdf 562 KB
language	eng
TextVersion	Publisher
departments	Medical Sciences