Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice

Sakai, Tohru; Shuto, Emi; Taki, Tomoyo; Imamura, Honami; Kioka, Miku; Nakamoto, Akiko; Mizoguchi, Seiji; Amano, Shouko; Kawano, Yukari; Nakamoto, Mariko; Tsutumi, Rie; Hosaka, Toshio

doi:10.2152/jmi.59.95

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ID	106005
著者	酒井, 徹 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 徳島大学教育研究者総覧 KAKEN研究者をさがす首藤, 恵泉 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School KAKEN研究者をさがすタキ, トモヨ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School イマムラ, ホナミ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School キオカ, ミク Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 中本, 晶子 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 徳島大学教育研究者総覧 KAKEN研究者をさがすミゾグチ, セイジ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School アマノ, ショウコ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School カワノ, ユカリ Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 中本, 真理子 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 徳島大学教育研究者総覧 KAKEN研究者をさがす堤, 理恵 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School 保坂, 利男 Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School
キーワード	cathepsin E dendritic cells MHC class II NC/Nga mice
資料タイプ	学術雑誌論文
抄録	NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)- immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.
掲載誌名	The journal of medical investigation : JMI
ISSN	13431420
cat書誌ID	AA11166929
巻	59
号	1-2
開始ページ	95
終了ページ	101
並び順	95
発行日	2012-02
EDB ID	269288
出版社版DOI	10.2152/jmi.59.95
出版社版URL	https://doi.org/10.2152/jmi.59.95
フルテキストファイル	LID201402042005.pdf 562 KB
言語	eng
著者版フラグ	出版社版
部局	医学系