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ID 116396
Title Alternative
Absolute lymphocyte count changes during neoadjuvant chemotherapy are associated with prognosis of HER2-positive breast cancer patients
HER2陽性乳癌の総リンパ球数の検討
Author
Miyamoto, Naoki Tokushima University
Inui, Tomohiro Tokushima University
Sasa, Soichiro Tokushima University
Keywords
HER2陽性乳癌
総リンパ球数
周術期化学療法
HER2 breast cancer
neoadjuvant chemotherapy
absolute lymphocyte counts
Content Type
Journal Article
Description
Purpose : Several studies have shown that peripheral hematologic parameters, such as the absolute lymphocyte count(ALC)and neutrophil to lymphocyte ratio(NLR)can predict the prognosis for malignant tumor. We investigated the relation of these parameter and prognosis before neoadjuvant chemotherapy for human epidermal growth factor receptor-2(HER2)-positive breast cancer patients.
Methods : From April 2009 to March 2019, 85 patients diagnosed with HER2‐positive breast cancer and treated with trastuzumab-based neoadjuvant chemotherapy were included in this retrospective cohort study. The optimal cut-off for the NLR and ALC was identified using the receiver operating characteristic(ROC)curve analysis and Youden’s index.
Results : The median age of patients at the start of treatment was 58.9(range 32‐81)years. The median follow-up time for HER2-positive breast cancer patients was 52.0(range:9.8‐114.3)months. In this period, 11 patients developed recurrence. The low-ALC group showed better disease free survival than the high-ALC group(p=0.0482). There was no significant difference in disease free survival between the low- and high-NLR groups.
Conclusion : ALC before neoadjuvant chemotherapy may be a predictor of prolonged disease free survival in HER2‐positive breast cancer patients.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
77
Issue
3-4
Start Page
131
End Page
136
Sort Key
131
Published Date
2021-08-25
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences