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ID 116396
タイトル別表記
Absolute lymphocyte count changes during neoadjuvant chemotherapy are associated with prognosis of HER2-positive breast cancer patients
HER2陽性乳癌の総リンパ球数の検討
著者
宮本, 直輝 徳島大学
乾, 友浩 徳島大学
笹, 聡一郎 徳島大学
キーワード
HER2陽性乳癌
総リンパ球数
周術期化学療法
HER2 breast cancer
neoadjuvant chemotherapy
absolute lymphocyte counts
資料タイプ
学術雑誌論文
抄録
Purpose : Several studies have shown that peripheral hematologic parameters, such as the absolute lymphocyte count(ALC)and neutrophil to lymphocyte ratio(NLR)can predict the prognosis for malignant tumor. We investigated the relation of these parameter and prognosis before neoadjuvant chemotherapy for human epidermal growth factor receptor-2(HER2)-positive breast cancer patients.
Methods : From April 2009 to March 2019, 85 patients diagnosed with HER2‐positive breast cancer and treated with trastuzumab-based neoadjuvant chemotherapy were included in this retrospective cohort study. The optimal cut-off for the NLR and ALC was identified using the receiver operating characteristic(ROC)curve analysis and Youden’s index.
Results : The median age of patients at the start of treatment was 58.9(range 32‐81)years. The median follow-up time for HER2-positive breast cancer patients was 52.0(range:9.8‐114.3)months. In this period, 11 patients developed recurrence. The low-ALC group showed better disease free survival than the high-ALC group(p=0.0482). There was no significant difference in disease free survival between the low- and high-NLR groups.
Conclusion : ALC before neoadjuvant chemotherapy may be a predictor of prolonged disease free survival in HER2‐positive breast cancer patients.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
77
3-4
開始ページ
131
終了ページ
136
並び順
131
発行日
2021-08-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院
医学系